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DMSO for Weight Loss: What the Evidence Shows

By Norma Ector · · Updated

dmso for weight loss
Contents

Have you heard that DMSO (dimethyl sulfoxide) can melt fat or speed up weight loss? The short answer is that there is no reliable evidence that it does.

In this article, we’ll explain what DMSO is, what it is actually approved for, why the weight-loss claims don’t hold up, and the safety risks of using DIY DMSO products.

DMSO is a colorless sulfur-containing solvent, produced mainly as a byproduct of the wood pulp industry. In the United States, its only FDA-approved human use is a 50% solution (Rimso-50) instilled into the bladder to relieve symptoms of interstitial cystitis.

It is also sold as an industrial solvent and as a veterinary product. Those products are not made for people to swallow or rub on their skin.

What Is Dmso And How Can It Help With Weight Loss?

DMSO has been studied for pain and inflammation, and it passes through skin very easily. That ability is why it is often marketed as a "carrier" for other substances.

There is no good human evidence that DMSO stimulates metabolism, burns fat, shrinks fat cells or reduces facial fat. Claims that it helps people lose weight "quickly and safely" are not supported.

The FDA-approved Rimso-50 label states that DMSO has not been approved as safe and effective for any use other than interstitial cystitis.

What Are The Benefits And Risks Of Using Dmso For Weight Loss?

how to use dmso for weight loss

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For weight loss, there are no proven benefits. No clinical trials show that DMSO reduces belly fat, cellulite or body weight in people.

The risks are real. The prescription label lists a garlic-like taste within minutes of use and breath and skin odor that can last up to 72 hours. It also warns that DMSO can release histamine and occasionally cause allergic-type reactions.

Because high doses caused eye lens changes in animals, the label calls for eye exams and periodic liver, kidney and blood tests during long-term treatment. Pregnant or breastfeeding women should not use DMSO products.

There are none. DMSO is sold in many forms, including creams, gels, and liquids, but no dose has been shown to cause weight loss.

Advice to use specific concentrations for fat loss, or to "start low and work up," comes from sellers and forums, not from medical evidence. Higher concentrations also raise the risk of skin irritation and burning.

How To Use Dmso For Weight Loss?

You shouldn’t. DMSO is sold in both liquid and cream form, and some sellers suggest rubbing it on the stomach or thighs to target fat. Spot fat loss from a skin product is not supported by evidence.

Because DMSO carries other substances through the skin, anything on your skin or in an impure product can be absorbed into your body too. Industrial and veterinary grades are not made for human use, and their purity is not guaranteed.

If you are considering DMSO for any health reason, talk with your doctor first, especially if you take other medicines or apply other topical products.

Are There Any Foods Or Supplements That Should Be Avoided When Using Dmso For Weight Loss?

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There is no evidence-based food list for DMSO, because it is not a weight-loss treatment. The bigger concern is what DMSO can carry into your body.

Do not mix DMSO with other creams, ointments or medicines on your skin unless a doctor tells you to. Tell your doctor or pharmacist about every supplement and medicine you use.

What Are The Possible Side Effects Of Using Dmso For Weight Loss?

Reported side effects include a garlic-like taste and breath or body odor, skin redness, itching and burning, headache, and allergic-type reactions.

Products of unknown purity add the risk of absorbing contaminants. Stop using any DMSO product and get medical help if you have trouble breathing, swelling or a widespread rash.

use dmso for weight loss

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The lifestyle changes that help with weight loss work without DMSO. Here are the basics:

TipHow ToBenefits
Exercise RegularlyAim for at least 150 minutes of moderate activity a week, such as brisk walking, cycling or swimming, plus 2 days of muscle strengthening.Burns calories, helps preserve muscle and supports heart health.
Eat Healthy FoodsBuild meals around vegetables, fruits, whole grains and lean protein, and limit sugary drinks and highly processed snacks.Makes it easier to eat fewer calories while still getting the nutrients you need.
Track Your ProgressWeigh yourself or measure your waist on a regular schedule.Helps you spot what is working and adjust early.

Are There Any Alternatives To Using Dmso For Weight Loss?

Yes, and they have far better evidence:

  1. Exercise – Regular physical activity helps you burn calories, keep muscle and maintain weight loss. The CDC recommends at least 150 minutes of moderate-intensity activity a week for adults.
  2. Diet Modification – Eating fewer calories than you burn, mostly from vegetables, fruits, lean proteins, whole grains and healthy fats, leads to gradual weight loss. Tracking intake with an app or journal can help.
  3. Medical treatment – For people with obesity, doctors can prescribe FDA-approved weight-loss medications, which require medical supervision. Bariatric surgery is another option for people who qualify.

What Is The Best Way To Store Dmso?

If you have a prescribed DMSO product, store it as the label directs. DMSO solidifies at cool room temperatures, about 65°F (18.5°C), and melts again without harm.

Keep any DMSO product tightly closed, in its original container, and out of reach of children and pets.

Are There Any Additional Tips To Consider When Using Dmso

Do not swallow or inject DMSO bought online, and do not use industrial or veterinary products on yourself. These products are not regulated for human use.

If a product promises fat loss, a "facelift in a jar" or a cure for a disease, treat that as a red flag. Talk to your doctor before using DMSO for any reason.

Conclusion

DMSO is not a weight-loss treatment. Its only FDA-approved human use is a bladder instillation for interstitial cystitis, and there is no reliable evidence that it burns fat.

DIY DMSO products carry risks, including skin reactions, allergic-type reactions and absorbing contaminants. Proven approaches, such as a calorie-controlled diet, regular activity and medical care when needed, are the safer path.

FAQs

What is DMSO and can it help with weight loss?

DMSO (dimethyl sulfoxide) is a colorless solvent made mainly as a byproduct of wood pulp processing. Its only FDA-approved human use is as a bladder instillation for interstitial cystitis.

There is no reliable evidence that it burns fat or causes weight loss.

No. There is no established or safe dose of DMSO for weight loss, because it has not been shown to work for that purpose.

Do not swallow, inject or apply DMSO products to lose weight.

Is DMSO cream or liquid safe to use for weight loss?

DMSO is sold as topical creams and oral liquids, but none is proven for weight loss. Products sold as industrial solvents or for animals are not made for human use, and their purity is not guaranteed.

DMSO passes through skin easily and can carry other substances with it, so contaminants on the skin or in the product can be absorbed too.

What side effects can DMSO cause?

Reported effects include a garlic-like taste and breath or body odor, skin irritation, headache and allergic-type reactions.

Long-term use of the prescription product requires eye exams and periodic liver, kidney and blood tests.

What works better than DMSO for weight loss?

A calorie-controlled diet, regular physical activity, enough sleep and support from a doctor or registered dietitian. For people with obesity, doctors can prescribe FDA-approved medications for weight loss under supervision.

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